Bacterial DNA Salivary Analysis
Periodontitis, a bacterial infection in the mouth, is the primary cause of tooth loss in adults. It is estimated that over 75% of all Americans over the age of 35 have some form of periodontal disease. Oral DNA laboratories offer several diagnostic tests that can render valuable information to your periodontist for the assessment, treatment and monitoring of your condition. The available tests are the following:
MY PERIO PATH – identifies and measures the type, as well as the concentration of specific periodontal pathogenic ( high, moderate, and low risk ) bacteria that can cause gingivitis and periodontitis.
CELSUS ONE – evaluates 8 gene markers associated with inflammation, a critical factor in periodontal disease, diabetes, and cardiovascular severity. These multiple genetic markers ( Interleukin 1 composite genotype, Interleukin 6, Interleukin 17A, Beta-defensin 17A, CD 14, Tumor necrosis factor alpha, Toll-like receptor 4 composite genotype, and Matrix metalloproteinase 3 ) provide powerful insight into the genetic component of the disease. The salivary samples are evaluated using target-enriched next-generation sequencing.
The reasons why these tests may be recommended are the clinical presence of infection (inflamed swollen, bleeding gums), bone loss around teeth with periodontal pockets, family history of periodontal disease, confirmation of oral health status prior to surgery, and for the assessment of your periodontal health and genetic risk to periodontal infections. These tests help personalize your treatment by establishing which patients are at risk even before clinical signs and symptoms appear. They are also valuable in determining which patients may require more aggressive treatment and aid in optimizing the timing of recall appointments. The testing procedures are quick, non-invasive, simple, and easy to perform.